Natdac Daclatasvir


Daclatasvir is an inhibitor of non-structural protein 5A (NS5A). Each film coated tablet contains: Daclatasvir Dihydrochloride equivalent to Daclatasvir 60 mg. Daclatasvir is white to yellow colour solid and freely soluble in water. Daclatasvir is prescribed for the treatment of patients with chronic HCV genotype 3 infections along with Sofosbuvir 400mg tablets. Daclatasvir has revolutionized the management of HEPATITIS C by offering Ribavirin and Peg-interferon free treatment for all the genotypes of Hepatitis C.



Detail of Medicine:

Mechanism of Action:

Daclatasvir is an inhibitor of HCV non-structural protein 5A (NS5A) therefore it binds to the N-terminus of NS5A and inhibits both viral RNA replication and virion assembly. An advantage of Daclatasvir is that it is very active against multiple Genotypes while Ledipasvir is primarily active only against Genotype 1. This is important as the most prominent form of Hepatitis C is Genotype 3.

Advantages of Dosages Daclatasvir:

  1. Shortest treatment duration irrespective of all Genotypes.
  2. High Tolerability and safety profile.
  3. Superior Efficacy in Hepatitis C Genotype 3.
  4. Studied in more than 13000 patients with cure rate of between 94% – 99%.
  5. Recommended by EASL and FDA approved.

Dosages & Administration:

The recommended dosage of Daclatasvir is 60 mg once daily in combination with Sofosbuvir for 3 months, to be taken orally with or without food. It is highly recommended to administer the drug under strict medical supervision and advice.

Side Effects:

  • Adverse events associated with the use of Daclatasvir in combination with Sofosbuvir may include the following:
  • Dizziness
  • Headache
  • Tiredness
  • Shortness of Breath
  • Weakness
  • Chest Pain


Each Bottle contains 28 tablets of Daclatasvir 60mg.


Store between 15°C and 25°C in a dry place. Keep out of the reach of children.